Applying pharmacogenomics in therapeutics by Xiaodong Feng, Hong-Guang Xie

By Xiaodong Feng, Hong-Guang Xie

Recent advances in high-throughput gene sequencing and different omics biotechnologies have served as a springboard for the sector of pharmacogenomics. Pharmacogenomics is now often permitted because the significant determinant of variable drug security, efficacy, and cost-effectiveness. as a result, frequent use of pharmacogenomics for sufferer care has turn into a severe requirement. there's an remarkable urgency for aspiring and practising clinicians to develop into educated on find out how to interpret facts from pharmacogenomic checking out in training for the way forward for healthcare―i.e., custom-made medicine.

Applying Pharmacogenomics in Therapeutics offers well timed insurance of the rules, perform, and capability of pharmacogenomics and customized medication. constituted of chapters contributed by means of well-established pharmacologists and scientists from US and chinese language academia and undefined, this authoritative text:

  • Demonstrates the best way to observe the rules of pharmacogenomics and its biotechnologies in sufferer care
  • Depicts using genetic biomarkers in drug discovery and improvement, laboratory medication, and scientific services
  • Describes the perform of pharmacogenomics within the remedy of cancers, cardiovascular illnesses, neurologic and psychiatric problems, and pulmonary diseases
  • Discusses the merging of pharmacogenomics and replacement drugs, in addition to the combination of pharmacogenomics into pharmacoeconomics

Each bankruptcy starts off with the major techniques, through in-depth explorations of case reviews or serious reviews of genetic variants/biomarkers, and concludes with questions for self-examination.

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33 34 Applying Pharmacogenomics in Therapeutics INTRODUCTION Pharmacogenetics studies the influence of genetic variations on drug efficacy, ­absorption, metabolism, elimination, and safety in healthy subjects and patients (Haga and LaPointe 2013; Johnson 2003; Shin et al. 2009).  In recent years, the development of biotechnology has paved the way for a new era of pharmacogenetics, which undertakes a genome-wide approach to study the effects of multiple genes on drug responses (Cordero and Ashley 2012; Pirmohamed 2001; Squassina et al.

Et al. Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones. Mol Pharmacol, 2003; 63(3): 732–41. , et al. Pharmacogenetics of toxic epidermal necrolysis. Expert Opin Pharmacother, 2010; 11(13): 2153–62. , et al. A marker for Stevens-Johnson syndrome …: Ethnicity matters. Pharmacogenomics J, 2006; 6(4): 265–8. Schawartz, J. and A. Pollack. Judge invalidates human gene patent. The New York Times, 2010. com/2010/03/30/business/30gene.

Pharmacogenomics, 2010; 11(9): 1331–40. 161. , K. Calzon, and J. Jenkins. Genetics content in nursing curriculum. Proceedings of the National Coalition for Health Professional Education in Genetics, 2006. A. and J. Jenkins. Genomics education in nursing in the United States. Annu Rev Nurs Res, 2011; 29: 151–72. 32 Applying Pharmacogenomics in Therapeutics 163. , et al. Survey on warfarin pharmacogenetic testing among anticoagulation providers. Pharmacogenomics, 2009; 10(11): 1853–60. 164. Marsh, S.

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