Annual Reports Medicinal Chemistry Volume 1 by By C.K. Cain

By By C.K. Cain

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2 , 542 (1965). E. DePerrot, Psychiat. , 146,341 (1963b. a, D. Bente, M. P. Engelmeier, K. Heinrich, H. Hippius and W. Schmitt. , 14,538 (1964). J. Angst acd H. Kind, Schweiz. Med. , 2, 759 (1964). 0. H. Arnold, H. Bauer and K. Cmyral. Arzneimittel-Forsch.. 14. 510 (1964). H. Freeman, M. R . Otkem, M. W. Kristofferson and C. K. Gorby, Curr. Therap. R e s . , 1, 655 (1965) * I. W. Sletten, X. Pichardo and S. Gershon, Cum. Therap. , 1, 609 (1965). J. H. Biel, in Advances in Chemistry Series, No.

4. Oripavine D e r i v a t i v e s One of t h e most i n t e r e s t i n g f i n d i n g s i n r s y e n t years has been that ring the o b s e r v a t i o n by Bentley and h i s c o l l e a g u e s expansion of morphine t o t h e s i x - r i n g 6,14-endoethenotetrahydrothebaine o r o r i p a v i n e s t r u c t u r e l e a d s t o agents of s u r p a s s i n g potency. 38 These compounds have been used extens i v e l y t o immobilize wild animals s i n c e t h e i r high potency makes d a r t i n g q u i t e f e a s i b l e and t h e i r s a f e t y r a t i o i n four-legged animals i s high.

F. H P f l i g e r and V. Burckhardt, i n Psychopharmacological Agents, Vol. I , ed. M. Gordon, Academic P r e s s , New York-London, 1964, 35. 1. 2. G. 6, a, =, . a, s, 2 m, 9. 9, m, z, m, Sect. I 28 - - CNS Agents B i e l , Ed. 48a. 49. 50 * 51. 52: 53. 54. 55. E. B. Sigg, Can. Psychiat. Assoc. , 4. Spec. Suppl.. 7 5 (1959). A. Kaumann. N. Basso and P. Armendia, J. Pharmacol. Exptl. , 54 (1965). R. C. Ursillo and J. Jacobsen, J. Pharmacol. Exptl. Therap.. 247 (1965). A. Jori and S. Garattini, J.

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