Animal cell technology: from biopharmaceuticals to gene by Leda R. Castilho

By Leda R. Castilho

Creation to animal cellphone know-how /, Animal cells: easy innovations /, Cloning and expression of heterologous proteins in animal cells /, phone metabolism and its keep an eye on in tradition /, tradition media for animal cells /, Post-translational amendment of recombinant proteins /, Mechanisms of mobilephone proliferation and mobile demise in animal telephone tradition in vitro /, Mathematical types for progress and product synthesis in animal mobilephone tradition /, Bioreactors for animal cells /, tracking and keep watch over of mobilephone cultures /, Animal mobile separation /, Product purification approaches /, qc of biotechnological items /, Regulatory elements /, highbrow estate /, Recombinant healing proteins /, Monoclonal antibodies /, Viral vaccines: strategies, rules, and bioprocesses /, Bioinsecticides /, mobile remedies and stem cells /, Gene treatment /; Paula Marques Alves, Manuel Jose Teixeira Carrondo, & Pedro Estilita Cruz --, Patricia Leo ... [et al.] --, Mariela Bollati-Fogolin & Marcelo A. Comini --, Paola Amable & Michael Butler --, Angela Maria Moraes, Ronaldo Zucatelli Mendonca, & Claudio Alberto Torres Suazo --, Michael Butler --, Maira Peixoto Pellegrini, Rodrigo Coelho Ventura Pinto, & Leda dos Reis Castilho --, Elisabeth F.P. Augusto, Manuel F. Barral, & Rosane A.M. Piccoli --, Ernesto Chico Veliz, Gryssell Rodriguez, & Alvio Figueredo Cardero --, Aldo Tonso --, Leda dos Reis Castilho & Ricardo de Andrade Medronho --, Angela Maria Moraes, Leda Castilho, & Sonia Maria Alves Bueno --, Marina Etcheverrigaray & Ricardo Kratje --, Maria Teresa Alves Rodrigues & Ana Maria Moro --, Ana Cristina Almeida Muller & Leila Costa Duarte Longa --, Maria Candida Maia Mellado & Leda dos Reis Castilho --, Wirla M.S.C. Tamashiro & Elisabeth F.P. Augusto --, Isabel Maria Vicente Guedes de Carvalho Mello ... [et al.] --, Marcia Regina da Silva Pedrini & Ronaldo Zucatelli Mendonca --, Hamilton da Silva Jr. & Radovan Borojevic --, Celio Lopes Silva ... [et al.]

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Process changes may require new licensing proce- Introduction to animal cell technology dures, and this makes the introduction of biosimilars in the market more difficult. (ii) Some of these proteins (for therapy) or VLPs (for vaccines such as hepatitis B) can be produced by yeast or even by Escherichia coli because of the limited requirement for post-translational modification (see Chapter 6). The total market value of biopharmaceuticals produced by E. coli or yeast was surpassed by those produced by animal cells only around 1996.

All these developments permitted the practical, efficient, and robust culture of animal cells in bioreactors at scales larger than 10 m3 for consistently producing safe and effective biopharmaceuticals. In the present book, Animal Cell Technology: From Biopharmaceuticals to Gene ˆ ngela M. Moraes, Elisabeth F. Pires Augusto and Therapy, editors Drs Leda R. Castilho, A Michael Butler have integrated the background knowledge and developments of the last 20 years that have converted the culture of animal cells into a vigorous and important scientific field.

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