By Michael W. Thompson, Louis B. Hersh (auth.), Nigel M. Hooper, Uwe Lendeckel (eds.)
Aminopeptidases in Biology and Disease presents a finished assessment of the rising position of aminopeptidases in various organic strategies and disorder occasions. methods as varied as angiogenesis, antigen presentation, neuropeptide and hormone processing, being pregnant and replica, protein turnover, reminiscence, irritation, tumour progress, melanoma and metastasis, blood strain and high blood pressure all severely contain a number of aminopeptidases. the person chapters were written by way of specialists within the box who've supplied distinctive money owed of the imperative roles performed by means of numerous aminopeptidases in biology and disease.
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Extra resources for Aminopeptidases in Biology and Disease
J. Biochem . 267: 2297-2306. , 1995, Evolutionary families ofmetallopeptidases. Meth . Enzymol. 248: 183-228. , 2002, New developments in frontotemporal dementia and parkinsonism linked to chromosome 17. Curro Opin. Neurol. , 1995, Degradation of dynorphin-related peptides by the puromycinsensitive aminopeptidase and aminopeptidase M. J. Neurochem. 65: 389-395 . , 2001, Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase.
Recent studies show that TNP-470 blocks S-phase entry in ECs by inhibiting Rb hyperphosphorylation through the activation of the p53 pathway (Figure 4). Treatment of primary ECs with cytostatic concentrations of TNP-470 inhibits cyelin E-cdk2 activity and subsequent Rb hyperphosphorylation through the p53-dependent induction of p21 WAFIICIPI (Yeh et al. 2000; Zhang et al. 2000). 3 Evidence that TNP-470 activates the p53 pathway by a unique mechanism in endothelial cells Although p53 and p21 WAF IICIPI are required for growth arrest of ECs by TNP-470, the cellular events that lead to p53 activation remain unclear.
2000). Thus, growth sensitivity to TNP-470 treatment is cell type-specific (Kusaka et al. 1994). The growth of endothelial cells, however, appears to be the most sensitive (Kusaka et al. 1994). Based on genetic evidence suggesting that cellular levels of Metinit hydrolysis activity directly correlate with growth rate in yeast (Chang et al. 1992), it has been proposed that differences in the combined expression of MetAPl and MetAP2 among cell types may account for differences in growth sensitivity to TNP-470 (Sin et al.