Aminopeptidases in Biology and Disease by Michael W. Thompson, Louis B. Hersh (auth.), Nigel M.

By Michael W. Thompson, Louis B. Hersh (auth.), Nigel M. Hooper, Uwe Lendeckel (eds.)

Aminopeptidases in Biology and Disease presents a finished assessment of the rising position of aminopeptidases in various organic strategies and disorder occasions. methods as varied as angiogenesis, antigen presentation, neuropeptide and hormone processing, being pregnant and replica, protein turnover, reminiscence, irritation, tumour progress, melanoma and metastasis, blood strain and high blood pressure all severely contain a number of aminopeptidases. the person chapters were written by way of specialists within the box who've supplied distinctive money owed of the imperative roles performed by means of numerous aminopeptidases in biology and disease.

Show description

Read or Download Aminopeptidases in Biology and Disease PDF

Similar biology books

Bacterial Toxins: Methods and Protocols (Methods in Molecular Biology Vol 145)

Skilled researchers describe in step by step aspect robust tools for the research of bacterial exo- and endotoxins. those cutting-edge strategies variety from purification and detection tools to equipment of conformational research, and comprise using phage antibody libraries and strategies of structural and sensible analyses of endotoxins.

The behavior and sensory biology of elasmobranch fishes: an anthology in memory of Donald Richard Nelson

The elasmobranch fishes contain the residing sharks, skates and rays which are vital contributors of approximately all marine ecosystems. Their huge measurement, secretive habit, and wide-ranging behavior lead them to tricky to watch within the box or to keep up in captivity. hence, little is understood approximately their usual habit and the way it's mediated via their sensory platforms.

Plant Evolutionary Biology

There are nonetheless heroes in technology. they're well-known as the concerns and difficulties they selected to review turned the problems and difficulties of a huge box of analysis. also they are famous simply because their insights and suggestions are those which are demonstrated and evaluated while new rules and applied sciences turn into to be had.

Advances in Fetal and Neonatal Physiology: Proceedings of the Center for Perinatal Biology 40th Anniversary Symposium

To have fun the heart for Perinatal Biology’s fortieth Anniversary, an illustrious workforce accumulated at Loma Linda college in February 2013. That collecting of specialists and this quantity of the lawsuits are a tribute to the founding father of the heart, Lawrence D. Longo, M. D. those chapters current contributions from people who indirectly or one other have been prompted via Dr.

Extra resources for Aminopeptidases in Biology and Disease

Example text

J. Biochem . 267: 2297-2306. , 1995, Evolutionary families ofmetallopeptidases. Meth . Enzymol. 248: 183-228. , 2002, New developments in frontotemporal dementia and parkinsonism linked to chromosome 17. Curro Opin. Neurol. , 1995, Degradation of dynorphin-related peptides by the puromycinsensitive aminopeptidase and aminopeptidase M. J. Neurochem. 65: 389-395 . , 2001, Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase.

Recent studies show that TNP-470 blocks S-phase entry in ECs by inhibiting Rb hyperphosphorylation through the activation of the p53 pathway (Figure 4). Treatment of primary ECs with cytostatic concentrations of TNP-470 inhibits cyelin E-cdk2 activity and subsequent Rb hyperphosphorylation through the p53-dependent induction of p21 WAFIICIPI (Yeh et al. 2000; Zhang et al. 2000). 3 Evidence that TNP-470 activates the p53 pathway by a unique mechanism in endothelial cells Although p53 and p21 WAF IICIPI are required for growth arrest of ECs by TNP-470, the cellular events that lead to p53 activation remain unclear.

2000). Thus, growth sensitivity to TNP-470 treatment is cell type-specific (Kusaka et al. 1994). The growth of endothelial cells, however, appears to be the most sensitive (Kusaka et al. 1994). Based on genetic evidence suggesting that cellular levels of Metinit hydrolysis activity directly correlate with growth rate in yeast (Chang et al. 1992), it has been proposed that differences in the combined expression of MetAPl and MetAP2 among cell types may account for differences in growth sensitivity to TNP-470 (Sin et al.

Download PDF sample

Rated 4.88 of 5 – based on 45 votes