Advances in veterinary science and comparative medicine. by James L Bittle; Frederick A Murphy

By James L Bittle; Frederick A Murphy

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28 J A M E S L. BITTLE A N D S U S I E M U I R Immunization. , 1969). This vaccine has been combined with infectious bovine rhinotracheitis virus and bovine virus diarrhea vaccines in multivalent formulations. , 1963). 2. Mumps Virus Mumps virus causes an acute infection in man with parotitis as the main clinical manifestation, although the central nervous system and other organs including the testes and ovaries can be affected. Mumps virus has a limited host range; in addition to man, only certain monkey species and laboratory rodents can be infected.

Tetani. The lethal dose of t h e toxin, however, is less t h a n t h a t required to induce an antibody response. 1. Clostridium perfringens Clostridium perfringens h a s five serotypes, A - E , classified according to the production of lethal exotoxins. Types A and C are pathogenic for man, whereas all five serotypes can affect animals (see Table I). Immunization. The exotoxins of C. perfringens are antigenic proteins t h a t can be detoxified for use in vaccines. The existence of common capsular antigens, which elicit cross-reactions between the serotypes, demonstrates t h e considerable heterogeneity of this group.

D. Bordetella The species in this genera, B. pertussis, B. bronchiseptica, and B. parapertussis, can be either parasites or, as in swine and dogs, common inhabitants of the upper respiratory tract. These small, serologically related bacilli produce a dermonecrotic toxin. , 1977). Local, not serum, antibody concentration is important in clearance of the infection. 48 J A M E S L. BITTLE A N D S U S I E M U I R 1. Bordetella pertussis The etiologic agent of whooping cough, Β. pertussis, produces two distinct hemagglutinins, leukocytosis-promoting factor-hemagglutinin (LPF-HA) and filamentous hemagglutinin (FHA), and various toxins (pertussis toxin [PT] and dermonecrotic toxin).

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