Advances in spinal fusion : molecular science, biomechanics, by Kai-Uwe Lewandrowski

By Kai-Uwe Lewandrowski

Advances in Spinal Fusion finds a brand new iteration of fabrics and units for more advantageous operations in spinal fusion. This reference showcases rising learn and applied sciences in parts reminiscent of biodegradable implants, drug supply, stem telephone isolation and transfection, phone encapsulation and immobilization, and the layout of second and 3D scaffolds for cells. It captures a cascade of suggestions an important to elevated therapeutic and lowered morbidity in spinal fusion equipment and mechanics and addresses present criteria in analytical method and qc, it describes the choice of biomaterials for better biocompatibility, biostability, and structure/function relationships.

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Mal Respir 1999; 16:215–217. 72. Schildhauer TA, Bennett AP, Wright TM, Lane JM, O’Leary PF. Intravertebral body reconstruction with an injectable in situ-setting carbonated apatite: biomechanical evaluation of a minimally invasive technique. J. Orthop. Res 1999; 17:67–72. 73. Fujita H, Nakamura T, Tamura J, Kobayashi M, Katsura Y, Kokubo T, Kikutani T. Bioactive bone cement: effect of the amount of glass-ceramic powder on bone-bonding strength. J. Biomed. Mater. Res 1998; 40:145–152. 74. Bai B, Jazrawi LM, Kummer FJ, Spivak JM.

Orthop. Trauma Surg 1985; 104:242–246. 68. Jasper L, Deramond H, Mathis JM, Belkoff SM. Evaluation of PMMA cements altered for use in vertebroplasty. Presented at the 10th Interdisciplinary Research Conference on Injectible Biomaterials, Amiens, France, March 14–15, 2000. 69. Padovani B, Kasriel O, Brunner P, Peretti-Viton P. Pulmonary embolism caused by acrylic cement: a rare complication of percutaneous vertebroplasty. AJNR Am. J. Neuroradiol 1999; 20:375–377. 70. Wilkes RA, MacKinnon JG, Thomas WG.

The spinal cord appears to be at little risk of thermal injury as long as the cement is properly injected and contained within the VB. If cement were to leak into the spinal canal and come into direct contact with the cord, it is not unrealistic to expect that thermal injury might occur. © 2004 by Marcel Dekker, Inc. B. Cytotoxicity The methylmethacrylate (MMA) monomer component of PMMA cement is cytotoxic and therefore has been implicated as a mechanism of pain relief [24]. Cell cultures show that MMA monomer is toxic to leukocytes and endothelial cells when concentrations exceed 10 mg/mL [38], but its effect on neural tissue remains unknown.

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