By E.W. Caspari, John G. Scandalios (Eds.)
This quantity in a sequence on genetics, emphasizes the range of genetic experiences. Articles hide the filamentous fungus neurospora, biogenesis of yeast ribosomes, evolutionary genetics of fish, drosophila transposable parts and the dropophila gene zeste.
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Extra info for Advances in Genetics, Vol. 23
In the wild type, liquid holding after irradiation potentiates cell lethality as opposed to the wellknown positive effect observed on the survival of s. cereuisiae under similar conditions. The very specific effect of caffeine on the main repair pathway of the fission yeast has to be emphasized since it provides a powerful tool for experimental studies. When the molecular mechanism involved in the major repair pathway is elucidated, our knowledge of the exact role of the repair processes in mutagenesis will become much clearer.
If DNA replication occurs before the correction has been completed, a gap results that can be repaired under appropriate conditions by one of the processes involving recombination. The breaks produced in either strand of the duplex by ionizing radiation fall into a similar category of lesions. The presence of a specific UV repair mechanism in the fission yeast was first suggested by Fabre (1970). Two independent pathways of recovery from UV-induced DNA injuries were suspected: one presumably con- RECOVERY A N D REPAIR IN Schizosaccharomyces 27 trolling recombination (absent from the U V S l , or rad 1-1, deficient strain) and a second one controlled by the UVSA gene and thought to direct the removal of prerecombinational lesions by a process resembling excision (absent from UVSA, or rad 13, defective mutant) (Fabre 1970, 1973).
Both repair mechanisms require the presence of a duplicated genome either at the time of irradiation or during the first round of division following irradiation. The identification of the main pathway of repair for radiation injuries in S. pombe as being related to a recombinational process has been essentially based on the observation that it occurs only in the presence of a duplicated genome. It has also been supported by the specific effect of the wellknown inhibitor caffeine, which unequivocally blocks the repair process that was independent of the excision process (Clarke, 1968; Schiipbach, 1971; Fabre, 1971).