Advances in Fetal and Neonatal Physiology: Proceedings of by Lubo Zhang, Charles A. Ducsay

By Lubo Zhang, Charles A. Ducsay

To have a good time the guts for Perinatal Biology’s fortieth Anniversary, an illustrious crew amassed at Loma Linda college in February 2013. That accumulating of specialists and this quantity of the court cases are a tribute to the founding father of the heart, Lawrence D. Longo, M.D. those chapters current contributions from people who in a roundabout way or one other have been prompted through Dr. Longo. overlaying quite a lot of subject matters, and illustrating the range of pondering and medical pursuits, those complaints deal with easy technology via to medical difficulties within the developmental programming of health and wellbeing and ailment.

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Advances in Fetal and Neonatal Physiology: Proceedings of the Center for Perinatal Biology 40th Anniversary Symposium

To have fun the guts for Perinatal Biology’s fortieth Anniversary, an illustrious staff accrued at Loma Linda collage in February 2013. That amassing of specialists and this quantity of the court cases are a tribute to the founding father of the guts, Lawrence D. Longo, M. D. those chapters current contributions from people who indirectly or one other have been motivated through Dr.

Extra resources for Advances in Fetal and Neonatal Physiology: Proceedings of the Center for Perinatal Biology 40th Anniversary Symposium

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2 sGC-cGMP Signaling: Target for Anticancer Therapy 13 53. Kumazoe M, Sugihara K, Tsukamoto S, Huang Y, Tsurudome Y, Suzuki T, et al. 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. J Clin Invest. 2013;123:787–99. 54. Frattola L, Carenzi A, Cerri C, Kumakura K, Trabucchi M. Regulation of the cyclic guanosine 3′–5′ monophosphate system in human brain tumors. Acta Neurol Scand. 1976;54:382–90. 55. Zhu H, Li JT, Zheng F, Martin E, Kots AY, Krumenacker JS, et al. Restoring soluble guanylyl cyclase expression and function blocks the aggressive course of glioma.

22. White AA, Aurbach GD. Detection of guanyl cyclase in mammalian tissues. Biochim Biophys Acta. 1969; 191:686–97. 23. Goridis C, Morgan IG. Guanyl cyclase in rat brain subcellular fractions. FEBS Lett. 1973;34:71–3. 24. Kimura H, Murad F. Evidence for two different forms of guanylate cyclase in rat heart. J Biol Chem. 1974; 249:6910–6. References 1. Murad F. Discovery of some of the biological effects of nitric oxide and its role in cell signaling. Biosci Rep. 1999;19:133–54. 2. Murad F. The 1996 Albert Lasker Medical Research Awards.

2 Study Design We exposed six pregnant sheep to high altitude (3,820 m) hypoxia from 30 to 135 days gestation (term 146 days). We then transferred the ewes to Loma Linda and instrumented them surgically as described above. Ten to 14 days after surgery we determined fetal cardiac output and organ blood flows by means of the radiolabeled microsphere technique during a baseline period and also during an additional 30-min period of more severe added acute hypoxemia. At this point doctors Takashi Okai and Masato Kamitomo, from Japan, had joined our team.

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